A recent study in Wuhan, China found that 36%  of patients who contracted COVID-19 had neurologic symptoms ranging from mild to severe neurological manifestations including  encephalopathy.  It could be due to virus-induced hyper inflammation, infection of CNS by the virus or immune response post infection.

Brain scans of patients with COVID-19 showed symptoms of acute necrotizing encephalopathy which might be a result of hyper inflammation caused by cytokine storm.   Which cytokines are involved in cytokine storm?  Learn more.

ACE2 receptor protein, the entry point of SARS-CoV-2 is expressed in the brain thus making it susceptible to viral infection.  Though the virus has not been detected yet, the detection of symptoms such as hyposmia suggests in involvement of the brain.   The neuroinvasive nature of the virus increases the risk of neurodegenerative disorders such as Parkinson's disease or multiplesclerosis.  Learn more about the proteins involved in Parkinsons disease and Neurodegenerative disease.

Are you looking for positive controls for your COVID-19 studies?  Find the controls for your target from the list 42 proteins and 8 over expression lysates.

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• References
  • Neurological Insights of COVID-19 Pandemic. Das et al, 2020
  • Key references for COVID19, Cytokines, Cytokine Storm