Interaction between immune checkpoint proteins such as PD-L1 and PD-1 found on surface of T cells interact resulting in T cell immune suppression but in cancer cells, this mechanism is suppressed leading to failure in detection of the abnormal cancer cells.

CTLA-4, PD-1, LAG-3, TIM-3, KIRs, and GITR are some of the major  immune checkpoint proteins. Learn about Immune checkpoint proteins and research tools

Why expression hosts selection  is critical for recombinant human protein synthesis?
One of the challenges of studying  a protein is to get a large quantities that close to the native protein.  Proteins expressed in  human cells such as HEK293  demonstrate

• Preservation of protein structure, post translational modifications, & functions
• Ideal for antibody production
• Studying protein-protein interaction

Learn more from this short video on 'Expression Hosts for Recombinant Proteins'

Interested in synthesizing custom proteins? 

Also for you

• Explore the Cytokines for Cancer Immunotherapy
• Listen to this short podcast on Cancer Diagnostics and PD-L1.

Popular videos

• Tumor-Related Immune Checkpoints and Therapy
• Biomarker Based Companion Diagnostics are enabling Precision Oncology

References

• Review: The Diverse Function of PD1/PD-L Pathway Beyond Cancer
• Review:  Immune checkpoint proteins:  a focus on PD1/PD-L1