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OriGene社 Liver diseases: Overview and Research Tools



8 Liver Diseases: Overview & Research Tools

Liver diseases, either acquired or inherited, follows through 4 specific stages which includes inflammation of liver, fibrosis, cirrhosis and end-stage.  Viral hepatitis, Alcoholic hepatitis, Non-alcoholic fatty liver disease (NAFLD), Non-alcoholicsteatohepatitis (NASH) liver cirrhosis, Hepatocellular carcinoma (HCC), Acute Immune Hepatitis (AIH) and Cholestasis are key liver diseases (1).

HSD17B13, Prothrombin (F2), miRNA10B, Insulin (INS),and FARSLB, are some of the key genes associated with liver diseases. Learn about genes involved in liver diseases.

Liver Disease Genes & Research Tools


17β-Hydroxysteroid dehydrogenases (HSD17Bs), a key enzyme in cholesterol and fatty acid metabolism, is upregulated in patients with non-alcoholic fatty liver disease (NAFLD).  Over expression of HSD17B13 is associated with lipid accumulation in liver.  Studies have shown that  HSD17B13 is a potential biomarker for advanced liver diseases such as NASH and liver cancer.  Read a post on HSD17B13 

COVID19 and Liver Diseases 

A recent study found that in patients with COVID-19 and liver disease, 57% of cases were severe with 17.65% mortality, thus showing increase risk in these patients group.  Learn more about COVID-19 related genes  (2)

Do you know: Why expression hosts selection  is critical for recombinant human protein synthesis?
One of the challenges of studying  a protein is to get a large quantities that close to the native protein.  Proteins expressed in human cells such as HEK293  demonstrate

  • Preservation of protein structure, post translational modifications, & functions
  • Ideal for antibody production
  • Studying protein-protein interaction
    Learn more from this short video on 'Expression Hosts for Recombinant Proteins'.

Interested in synthesizing custom proteins? Ask for a quote


1. Review: Role of HSD17B13 in liver physiology and pathophysiology
2. Review: Prognosis of COVID19 in patients with liver and kidney diseases

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