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OriGene社 New eBook on Traumatic Brain Injury: Overview & Research Tools



New eBook: Biomarkers in Traumatic Brain Injury

Traumatic brain injury (TBI) results from external forces applied to the brain in the form of head impact, acceleration, deceleration, or object penetrance. Neurological and psychological symptoms of TBI range from an acute mild headache to persistent loss of function. TBI is most often classified as mild, moderate, or severe based on the post-injury symptom profile and the discovery and validation of biomarkers that reliably predict both tissue damage severity and patient outcomes, could substantially improve clinical care. Damage-associated biomarkers are released into the extracellular space within the central nervous system (CNS) following injury. Validation of biomarkers as a diagnostic criterion for TBI requires profiling of several factors, including (1) time-course, (2) confounding factors, and (3) predictive accuracy. Learn more in this short review.




Potential Biomarkers in TBI



UCHL1 is a neuron-specific enzyme that has been used as a diagnostic biomarker in TBI blood tests. It is highly expressed in brain, testes, and carcinomas of various tissue origins. Many studies have shown a significant negative correlation between UCHL1 levels and the severity of TBI outcome. Learn more here.



GFAP is an intermediate filament protein found in different cells of the central nervous system (CNS). It is a specific biomarker that can be used for the evaluation of TBI patients. Previous studies have shown GFAP has good diagnostic accuracy in differentiating mild TBI patients from non-TBI controls.



Tools for TBI Research

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IHC staining of Carcinoma of Human pancreas tissue using anti-UCHL1 (PGP9.5) mouse monoclonal antibody.


IHC staining of Human breast tissue within the normal limits using anti-GFAP mouse monoclonal antibody at 1:150.


IHC staining of Carcinoma of Human lung tissue using anti-UCHL1 (PGP9.5) mouse monoclonal antibody.

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