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The upregulation of TP53 has been shown to promote p53-induced apoptosis and growth arrest in various tumor types. A recent study by Tripathi et al., noted that the use of Anthraquinone, a common anticancer agent used in therapeutics, upregulates p53 by inhibiting MDM2 in both cell cultures and animal models with leukemia. 

In another study by Wu et al., OriGene's P53 Lenti-ORF plasmid (RC225604L1) was used to upregulate P53 expression in glioma U-118 MG and A172 cells. The study aimed to investigate the interactions between P53 and RAD18 and their effects on radiation therapy. Upregulation of P53 was found to weaken the role of RAD18 upregulation and enhance the effects of radiation on cell inhibition and apoptosis promotion. Click here to read the full paper.

Lentiviral Products

We offer a comprehensive list of solutions that allow researchers to create their own lentiviral overexpression/shRNA particles. Scientists also take advantage of our lentiviral packaging service to save time and effort. 

Product Highlight:   With OriGene's Lentiviral Concentrator, low titer particles can be concentrated quickly, easily reaching up to 109 TU/mL. Just mix 4 volume of lentiviral supernatant with 1 volume of the Lentivirus Concentration Solution, incubate for a short time at 4⁰C or on ice, then spin the mixture in a standard centrifuge. You’ll increase your lentivirus titer up to 100 fold in 2 hours. Our concentrator has been cited in the Journal of Atherosclerosis, Genome Research, Molecular & Cellular Proteomics, and more!