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OriGene社 Why NKG2 is being studied?

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Why there is an increasing interest in NKG2 protein family?

 

Natural killer (NK) cells are innate lymphocytes that mediate lysis of tumor cells with NKG2D receptor.  MICA/B are NKG2D ligands downregulated in tumor cells via interesting mechanisms such as cleavage of extracellular domains by surface proteases.  MICA/B proteins are upregulated in multiple cancers in response to cellular stress pathways associated with malignant transformation such as DNA damage and accumulation of misfolded proteins.  Ability to restore NKG2D-mediated destruction of cancer cells is a critical immunotherapy strategy.  Read this interesting review. 

 

How can you analyze NKG2D proteins and its ligand MICA/B  gene family and proteins? Click below for tools to analyze

 

NKG2D     MICA     MICB

 

In addition to proteins and clones, OriGene offers  a range antibodies (TrueMAB)  to analyze NKG2D and its ligands. For list of antibodies, click here.

 

                             Anti-NKG2D      Anti-MICA       Anti-MICB

 

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