OriGene社 Why NKG2 is being studied?
Natural killer (NK) cells are innate lymphocytes that mediate lysis of tumor cells with NKG2D receptor. MICA/B are NKG2D ligands downregulated in tumor cells via interesting mechanisms such as cleavage of extracellular domains by surface proteases. MICA/B proteins are upregulated in multiple cancers in response to cellular stress pathways associated with malignant transformation such as DNA damage and accumulation of misfolded proteins. Ability to restore NKG2D-mediated destruction of cancer cells is a critical immunotherapy strategy. Read this interesting review.
How can you analyze NKG2D proteins and its ligand MICA/B gene family and proteins? Click below for tools to analyze
In addition to proteins and clones, OriGene offers a range antibodies (TrueMAB) to analyze NKG2D and its ligands. For list of antibodies, click here.
Fount of Information は、新商品、新規取扱メーカーなどの情報をいち早く紹介するコンテンツです。情報発信のスピードを重視しているコンテンツのため、現時点で法規制や取り扱いを確認できていない商品、定価を設定できていない商品があります。ご要望やご照会を受けた商品について、法令整備や在庫の充実を図ります。