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PBL Assay Science社 　VeriKine™カニクイザル/アカゲザルIFN-α 血清ELISA Kit

ヒト以外の霊長類IFN-αの高感度測定

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VeriKineTM Cynomolgus/Rhesus IFN-α Serum ELISA Kit 

 

Product Benefits:
• Enables sensitive detection of IFN-α to as low as 25 pg/ml
• Reproducible results with excellent inter- and intra-assay % CV (<15%)
• Quantifies IFN-α2 in serum, plasma and tissue/cell culture media
• Provides greater NHP IFN-α detection sensitivity and matrix compatibility than traditional human IFN-α ELISA kits
• Provides strong specificity for cynomolgus and rhesus IFN-α2

 

 

Non-human primates (NHP) are considered a preferred model for the study of human diseases due to a close phylogenetic relationship to humans. The model is crucial to the elucidation of pathological mechanisms and may enable the development of novel diagnostic and therapeutic tools. Studies of innate and adaptive immunity, pharmacodynamics (PD), and immunotoxicology of interferon stimulating/inhibiting molecules, as well as Emerging Infectious Disease (EID) models, can all be further advanced with an interferon immunoassay that is designed specifically for NHP.

 

 

The interferon alpha gene family is comprised of multiple distinct genes that occupy a single chromosomal locus, and the congener proteins are produced and secreted by most somatic cells in response to pathogen exposure. Cynomolgus and Rhesus macaques have recently been shown to produce IFN alpha gene subtypes in response to Toll-like receptor agonist exposure1. The Cynomolgus/Rhesus IFN-alpha ELISA Kit has been developed to measure the presence of non-human primate IFN-alpha 2 in serum or tissue culture media samples by a sensitive sandwich enzyme linked immunosorbent assay (ELISA). 

 

                      Figure 1. Standard curves in different sample matrices

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                              Cynomolgus Interferon Alpha 2 (pg/ml)

 

 

 

                      Figure 2. Specifically designed for detecting NHP IFN-α
                      Greater NHP IFN-α detection sensitivity and matrix compatibility.

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                                 Cynomolgus Interferon Alpha 2 (pg/ml) 

 

 

 

Catalog No.  Description  Size
46100-1  VeriKineTM Cynomolgus/Rhesus IFN-α Serum ELISA Kit
Compatibility: Serum, Plasma and Cell Culture Supernatant
Assay Range: 25 - 1600 pg/ml
No cross-reactivity with human IFN-γ, mouse IFN-α, or rat IFN-α		 1 x 96-well plate

 

 

 

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