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Tocris社 エピジェネティクス関連製品

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Epigenetics can be defined as acquired changes in chromatin structure that arise independently of a change in the underlying DNA nucleotide sequence. Epigenetic modifications - including acetylation, methylation, phosphorylation, and ubiquitination, amongst others - alter the accessibility of DNA to transcription machinery. Below you will find a sample of Tocris products related to epigenetics.

 

 

 

Cat. No. Product Name Activity
14.3.3 Proteins
2145 Difopein  High affinity inhibitor of 14.3.3 proteins; induces apoptosis
2144 R18 Inhibitor of 14.3.3 proteins; induces apoptosis
Bromodomains
4650 I-BET 151 hydrochloride BET bromodomain inhibitor
4499 (+)-JQ 1  Potent and selective BET bromodomain inhibitor
4445 PFI 1  BET bromodomain inhibitor
DNA Methyltransferases
2624 Decitabine DNA methyltransferase inhibitor
4359 Lomeguatrib MGMT inhibitor
3295 RG 108 Non-nucleoside DNA methyltransferase inhibitor
Histone Acetyltransferases
3084 Anacardic acid  Noncompetitive PCAF/p300 HAT inhibitor
4200 C 646  Selective p300/CBP HAT inhibitor
Histone Deacetylases
4593 GSK J1 Potent histone demethylase JMJD3/UTX inhibitor
4594 GSK J4 Histone demethylase JMJD3/UTX inhibitor; cell permeable
4077 MC 1568 Selectively inhibits HDAC class II (IIa)
3747 NCH 51 Histone deacetylase inhibitor
4403 Pyroxamide Histone deacetylase inhibitor
3810 SBHA Histone deacetylase inhibitor
2682 Sodium 4-Phenylbutyrate Histone deacetylase inhibitor
4270 TC-H 106 Class I histone deacetylase inhibitor
3852 Tranylcypromine hydrochloride Irreversible inhibitor of MAO-A, MAO-B and LSD1
1406 Trichostatin A Histone deacetylase inhibitor
3402 Tubacin HDAC 6 inhibitor; inhibits α-tubulin deacetylation
Histone Methyltransferases
3364 BIX 01294 G9a-like protein and G9a histone lysine methyltransferase inhibitor
4504 Chaetocin Selective histone methyltransferase SUV39H1 inhibitor
3861 UNC 0224 Potent G9a histone lysine methyltransferase inhibitor
4343 UNC 0638  Selective G9a and GLP histone lysine methyltransferase inhibitor
4342 UNC 0646  Potent and selective G9a/GLP inhibitor
Hypoxia Inducible Factors
4408 DMOG Prolylhydroxylase inhibitor
4451 IOX 2 Potent, selective HIF1α prolyl hydroxylase-2 (PHD2) inhibitor
JAK
1571 Cucurbitacin I  Selective inhibitor of STAT3/JAK2 signaling
4338 NSC 33994 JAK2 inhibitor
MBT Domains
4666 UNC 1215  Potent and selective L3MBTL3 domain inhibitor
4516 UNC 926 hydrochloride Binds the MBT domain of L3MBTL1 polycomb group protein
Poly(ADP-ribose) Polymerase
3735 BYK 49187 PARP-1 and PARP-2 inhibitor
1401 NU 1025 Potent PARP inhibitor
3255 PJ 34 hydrochloride Potent PARP inhibitor
3748 XAV 939 Tankyrase inhibitor; inhibits Wnt signaling
Protein Serine/Threonine Phosphatases
1136 Okadaic acid  Protein phosphatase 1 and 2A inhibitor
2613 NSC 87877 Potent inhibitor of shp2 and shp1 PTP

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