Tocris Bioscience社 エピジェネティクス関連製品
Epigenetics can be defined as acquired changes in chromatin structure that arise independently of a change in the underlying DNA nucleotide sequence. Epigenetic modifications - including acetylation, methylation, phosphorylation, and ubiquitination, amongst others - alter the accessibility of DNA to transcription machinery. Below you will find a sample of Tocris products related to epigenetics.
| Cat. No. | Product Name | Activity |
| 14.3.3 Proteins | ||
| 2145 | Difopein | High affinity inhibitor of 14.3.3 proteins; induces apoptosis |
| 2144 | R18 | Inhibitor of 14.3.3 proteins; induces apoptosis |
| Bromodomains | ||
| 4650 | I-BET 151 hydrochloride | BET bromodomain inhibitor |
| 4499 | (+)-JQ 1 | Potent and selective BET bromodomain inhibitor |
| 4445 | PFI 1 | BET bromodomain inhibitor |
| DNA Methyltransferases | ||
| 2624 | Decitabine | DNA methyltransferase inhibitor |
| 4359 | Lomeguatrib | MGMT inhibitor |
| 3295 | RG 108 | Non-nucleoside DNA methyltransferase inhibitor |
| Histone Acetyltransferases | ||
| 3084 | Anacardic acid | Noncompetitive PCAF/p300 HAT inhibitor |
| 4200 | C 646 | Selective p300/CBP HAT inhibitor |
| Histone Deacetylases | ||
| 4593 | GSK J1 | Potent histone demethylase JMJD3/UTX inhibitor |
| 4594 | GSK J4 | Histone demethylase JMJD3/UTX inhibitor; cell permeable |
| 4077 | MC 1568 | Selectively inhibits HDAC class II (IIa) |
| 3747 | NCH 51 | Histone deacetylase inhibitor |
| 4403 | Pyroxamide | Histone deacetylase inhibitor |
| 3810 | SBHA | Histone deacetylase inhibitor |
| 2682 | Sodium 4-Phenylbutyrate | Histone deacetylase inhibitor |
| 4270 | TC-H 106 | Class I histone deacetylase inhibitor |
| 3852 | Tranylcypromine hydrochloride | Irreversible inhibitor of MAO-A, MAO-B and LSD1 |
| 1406 | Trichostatin A | Histone deacetylase inhibitor |
| 3402 | Tubacin | HDAC 6 inhibitor; inhibits α-tubulin deacetylation |
| Histone Methyltransferases | ||
| 3364 | BIX 01294 | G9a-like protein and G9a histone lysine methyltransferase inhibitor |
| 4504 | Chaetocin | Selective histone methyltransferase SUV39H1 inhibitor |
| 3861 | UNC 0224 | Potent G9a histone lysine methyltransferase inhibitor |
| 4343 | UNC 0638 | Selective G9a and GLP histone lysine methyltransferase inhibitor |
| 4342 | UNC 0646 | Potent and selective G9a/GLP inhibitor |
| Hypoxia Inducible Factors | ||
| 4408 | DMOG | Prolylhydroxylase inhibitor |
| 4451 | IOX 2 | Potent, selective HIF1α prolyl hydroxylase-2 (PHD2) inhibitor |
| JAK | ||
| 1571 | Cucurbitacin I | Selective inhibitor of STAT3/JAK2 signaling |
| 4338 | NSC 33994 | JAK2 inhibitor |
| MBT Domains | ||
| 4666 | UNC 1215 | Potent and selective L3MBTL3 domain inhibitor |
| 4516 | UNC 926 hydrochloride | Binds the MBT domain of L3MBTL1 polycomb group protein |
| Poly(ADP-ribose) Polymerase | ||
| 3735 | BYK 49187 | PARP-1 and PARP-2 inhibitor |
| 1401 | NU 1025 | Potent PARP inhibitor |
| 3255 | PJ 34 hydrochloride | Potent PARP inhibitor |
| 3748 | XAV 939 | Tankyrase inhibitor; inhibits Wnt signaling |
| Protein Serine/Threonine Phosphatases | ||
| 1136 | Okadaic acid | Protein phosphatase 1 and 2A inhibitor |
| 2613 | NSC 87877 | Potent inhibitor of shp2 and shp1 PTP |
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