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Tocris社 Check out this months new product releases!

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Your Trusted Supplier of Innovative and High-Performance Life Science Reagents

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Read on to see five exciting new products from our comprehensive catalog of high performance research reagents.

For a complete list of all our new products, please  visit our website.

Potent and Selective BTK Degrader - DD 03-171 
(Cat. No. 7160)

  • Potent and selective Degrader of Bruton's tyrosine kinase (BTK; DC50 = 5.1 nM)
  • Induces proteasome- and cereblon-dependent BTK degradation
  • Suppresses BTK signaling and cell proliferation in mantle cell lymphoma (MCL) cells
  • Reduces tumor burden and extends survival in lymphoma patient-derived xenograft models

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Coronavirus Mpro Inhibitor  -
MPro N3 
(Cat. No. 7230)

  • Coronavirus main protease (Mpro) inhibitor (IC50 values are 2.7, 4 and 8.8 μM for MHV-A29, HCoV-229E and FOPV replication in vitro, respectively)
  • Inhibits viral cell infection in an MHV plaque reduction assay
  • Also inhibits SARS-CoV-2 viral cell entry in a plaque reduction assay (IC50 = 16.8 μM)

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Potent p300/CBP Inhibitor  - iP300w  (Cat. No. 7270)

  • Inhibits p300-mediated H3K9 acetylation (IC50 = 33 nM)
  • Inhibits cytotoxicity of DUX4 and overexpression of DUX4 target genes in vitro
  • Also impairs DUX4-mediated transcription in an animal model of facioscapulohumeral muscular dystrophy (FSHD)

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Deoxynucleotides for PCR  - dNTP solution mix  (Cat. No. 7272)

  • Mixture of deoxynucleotides, dATP, dCTP, dGTP, dTTP, in equimolar concentrations
  • Component of the DNA amplification mixture for polymerase chain reaction (PCR)

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