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Read on to see five exciting new products from our comprehensive catalog of high performance research reagents.

For a complete list of all our new products, please  visit our website.

Potent and Selective BTK Degrader - DD 03-171 
(Cat. No. 7160)

• Potent and selective Degrader of Bruton's tyrosine kinase (BTK; DC₅₀ = 5.1 nM)
• Induces proteasome- and cereblon-dependent BTK degradation
• Suppresses BTK signaling and cell proliferation in mantle cell lymphoma (MCL) cells
• Reduces tumor burden and extends survival in lymphoma patient-derived xenograft models

Coronavirus M^pro Inhibitor  -
MPro N3  (Cat. No. 7230)

• Coronavirus main protease (M^pro) inhibitor (IC₅₀ values are 2.7, 4 and 8.8 μM for MHV-A29, HCoV-229E and FOPV replication in vitro, respectively)
• Inhibits viral cell infection in an MHV plaque reduction assay
• Also inhibits SARS-CoV-2 viral cell entry in a plaque reduction assay (IC₅₀ = 16.8 μM)

Potent p300/CBP Inhibitor  - iP300w  (Cat. No. 7270)

• Inhibits p300-mediated H3K9 acetylation (IC₅₀ = 33 nM)
• Inhibits cytotoxicity of DUX4 and overexpression of DUX4 target genes in vitro
• Also impairs DUX4-mediated transcription in an animal model of facioscapulohumeral muscular dystrophy (FSHD)

Deoxynucleotides for PCR  - dNTP solution mix  (Cat. No. 7272)

• Mixture of deoxynucleotides, dATP, dCTP, dGTP, dTTP, in equimolar concentrations
• Component of the DNA amplification mixture for polymerase chain reaction (PCR)