Fount of Information

Tocris社 Exciting New Technologies for Neuroscience Research

この製品に関するご意見・ご照会・お問合せはこちら
Exciting_New_Technologies_for_Neuroscience_Research_1.png

Your Trusted Supplier of Innovative and High-Performance Life Science Reagents

Exciting_New_Technologies_for_Neuroscience_Research_2.png

Recent advances in neuroscience have provided researchers with new state of the art tools to investigate the complex neural networks underlying behaviors in health and disease. These include:

Chemogenetic Tools

We have recently expanded our range of chemogenetic tools. As well as DREADD ligands, our range now includes ultrapotent PSEMs (uPSEMs) for the modulation of neuronal activity  in vivo, via chimeric ion channels known as PSAMs.

Exciting_New_Technologies_for_Neuroscience_Research_3.png

Deschloroclozapine (DCZ)

Deschloroclozapine is a highly potent and selective hM3Dq and hM4Di DREADD agonist, which displays superior specificity and blood brain barrier penetration making it an excellent
option for in vivo electrophysiology experiments. 

View Product

Exciting_New_Technologies_for_Neuroscience_Research_4.png

uPSEM 817

Selective ultrapotent agonist for PSAM 4-GlyR and PSAM 4-5-HT 3 chimeric ion channels. Suppresses firing of layer 2/3 cortical neurons expressing  PSAM4-GlyR in brain slices. Brain penetrant in vivo

View Product

Featured Caged Compounds

Caged compounds enable the precise timed release of ligands adjacent to their receptors, reducing the effects of diffusion on the size and kinetics of the receptor’s response to the ligand. This is particularly useful in complex tissues preparations such as brain slices.

Cat. No.

Product Name

Description

1490

MNI-caged-L-glutamate

Stable photoreleaser of L-glutamate

3400

RuBi-GABA

Caged GABA; excitable at visible wavelengths

5948

DMNPE-4 AM-caged-calcium

Caged calcium; cell-permeable

6354

CNV Dopamine

Caged dopamine; photolysed by UV light

6553

JF-NP-26

Caged Raseglutarant (Cat. No. 4416); negative allosteric modulator of mGlu5 receptors

6700

PA Nic

Caged nicotine; photoactivated by one-photon and two-photon excitation

Exciting_New_Technologies_for_Neuroscience_Research_5.gif

False Fluorescent
Neurotransmitters (FFNs)

FFNs are fluorescent substrates for neurotransmitter transporters, which allow imaging of synaptic vesicles within the nerve terminal and synaptic cleft.

  • FFN 102 - DAT and VMAT2 substrate
  • FFN 270 - NET and VMAT2 substrate

     View All FFNs   

Fount of Information は、新商品、新規取扱メーカーなどの情報をいち早く紹介するコンテンツです。情報発信のスピードを重視しているコンテンツのため、現時点で法規制や取り扱いを確認できていない商品、定価を設定できていない商品があります。ご要望やご照会を受けた商品について、法令整備や在庫の充実を図ります。