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Tocris Bioscience社 Expanded DREADD Ligand Range

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We have recently expanded our range of DREADD ligands for in vitro and in vivo control of neuronal activity, and investigation of GPCR signaling pathways.

Scroll down to find our more about our new compounds, and alternative tools for neuronal control. 
New Potent Muscarinic DREADD Agonists

Product Name

Cat. No.

Reference

Deschloroclozapine (DCZ)

7193

Nagai et al (2020) PMID: 32632286

JHU 37152

7197

Bonaventura et al (2019) PMID: 31604917

JHU 37160

7198

Bonaventura et al (2019) PMID: 31604917

Ion Channel Chemogenetics

DREADDs, based on GPCRs, engage complex intracellular signaling pathways that result in changes in ion flux through endogenously expression channels. PSAMs are chimeric ion channels that provide direct manipulation of ion flux and neuronal activity.

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