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Chemical Inducer of Protein Dimerization - AP 1903 

(Cat. No. 6130)

• Protein dimerizer for use in FKBP fusion protein systems
• Exhibits >50-fold selectivity for FKBP^F36V over wild-type FKBP
• Induces apoptosis in cells expressing FKBP^F36V-Fas receptor intracellular domain fusion protein
• Also induces apoptosis in inducible caspase 9 (iCas9) suicide gene system
  

Potent CD38 Inhibitor  -
CD38 inhibitor 78c  (Cat. No. 6391)

• Potent CD38 (ADP ribosyl cyclase)      inhibitor (IC₅₀ = 2 - 7 nM)
• Catalyzes breakdown of NAD to nicotinamide and ADPR, and hydrolyzes NAADP to adenosine-5'-O-diphosphoribose phosphate
• Improves glucose intolerance, cardiac function and improves physiological and metabolic parameters in old mice
  

Potent BRD9 Degrader  -
dBRD9-A  (Cat. No. 6943)

• Potent BRD9 degrader
• Selectively binds to BRD9 and elicits near complete degradation at nanomolar concentrations
• Inhibits growth of synovial sarcoma cells in vitro, and tumor progression in a synovial sarcoma xenograft mouse model

Viral RNA-dependent RNA Polymerase Inhibitor  - Remdesivir (Cat. No. 7226)

• Viral RNA-dependent RNA polymerase (RdRp) inhibitor
• Exhibits activity against a range of      viruses in vitro
• Displays antiviral efficacy in animal      models of MERS-CoV and EBOV infection
• Broad spectrum, antiviral nucleotide prodrug; metabolized to active form GS 441524 (Cat. No. 7227)

Fluorescent dsDNA Probe  - Nucleic Acid Dye Green I  (Cat. No. 7246)

• Cyanine dye that specifically binds to double stranded DNA (dsDNA)
• Used in quantitative PCR protocols
• Can also be used in Loop-Mediated      Isothermal Application (LAMP) assays
• Excitation/emission maximum - 495/520 nm