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Tocris社 Highly Potent DREADD Ligands And PSEMs

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Chemogenetics enables control of neuronal activity, investigation of neuronal networks,

and interrogation of intracellular signaling pathways. Tocris offers a wide range of

chemogenetic compounds including highly potent DREADD ligands and PSEMs for in

vitro and  in vivo use.

  

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Deschloroclozapine (DCZ)

  • Highly potent & selective hM3Dq and hM4Di activator
  • Superior specificity and brain penetration
  • Highly suitable for in vivo use 

 

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uPSEM 817 

  • Ultrapotent agonist for PSAM4-GlyR & PSAM4-5-HT3 chimeric ion channels
  • Suppresses firing of neurons expressing PSAM4-GlyR
  • Brain penetrant in vivo

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Chemogenetics Research Bulletin

Want to know more about the chemogenetics and the development of DREADD ligands and PSEMs?

This research bulletin provides an introduction to chemogenetics and ligand development, and gives examples of how researchers use chemogenetic compounds. 

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