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TriLink社 Benefits of Enzyme-Mediated Extracellular Vesicle Engineering

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Benefits of Enzyme-Mediated Extracellular Vesicle Engineering


Extracellular vesicles (EVs) are cell-derived membranous particles that transfer proteins and nucleic acids to mediate intercellular communication. In recent years, they have been exploited as tools for drug delivery, largely due to their innate biocompatibility – not only are EVs readily able to bypass cellular barriers, but they are also stable during circulation. One way of directing EVs to specific cell types is by attaching targeting ligands to their surface. However, current methods for EV engineering are laborious and/or inefficient, highlighting the need for an alternative approach. An article published by Pham et al. in the Journal of Extracellular Vesicles describes the use of protein ligases for...

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CleanCap®: Your mRNA Capping Solution

Why are therapeutic and vaccine programs choosing CleanCap for their mRNA capping strategy? CleanCap offers the superior performance of a natural Cap 1 structure, versus the immunogenic Cap 0 structure that legacy cap analogs produce. With a streamlined co-transcriptional capping process and 3x the yield of capped mRNA, CleanCap accelerates your manufacturing timelines. 

  • Natural Cap 1 structure
  • Improved yield of capped mRNA
  • AG, GG, and AU analogs available to fit your sequence

Learn how CleanCap can benefit your program.

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