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TriLink BioTechnologies社 May TriLink Messenger

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RESEARCH NEWS
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Targeted Delivery of mRNA Therapeutics—4 Recent Examples

For mRNA therapeutic agents, which are unstable toward RNases and are not efficiently taken up by cells, encapsulation or complexation in nanoparticles is generally used for delivery. This blog discusses recent examples of targeting moieties for lipid nanoparticle (LNP) delivery of mRNA to specific cells of interest as possible therapeutics.

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Uncovering the role of TRAIL in cancer metastasis An antibacterial mRNA-LNP vaccine protects against the bubonic plague

Researchers at the VIB Center for Cancer Biology used TriLink’s CleanCap® to produce TRAIL mRNA for targeted delivery to endothelial cells, which represents a promising strategy to prevent cancer metastasis.

Researchers at the Tel Aviv University used TriLink manufactured mRNA in an optimized vaccine for bubonic plague, which has been shown to protect mice against a lethal Y. pestis challenge.

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