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RESEARCH NEWS

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Lyophilized mRNA Vaccines Advance to Clinical Trials


The remarkable success of the COVID-19 vaccines developed by Pfizer/BioNTech and Moderna is due to the combination of two technology platforms: mRNA vaccinology and lipid nanoparticle (LNP) delivery. Now they are taking it a step further by testing a lyophilized COVID-19 mRNA-LNP vaccine. In our most recent Zone In With Zon blog we are looking at what lyophilizing is, why it is important, and how two mRNA vaccines advance to clinical trials.

 

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Dual antigen self-amplifying RNA vaccines promise enhanced protection against SARS-CoV-2

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IL-1 and IL-1ra Regulate the Inflammatory Response to RNA Vaccines

A dual-antigen self-amplifying RNA vaccine has been shown to induce potent humoral and cellular immune responses that offer protection against emerging variants of SARS-CoV-2. Read on to learn more about the advantages of saRNA vaccines and why accelerating their development is important.​​​​

 

 

With RNA vaccines seeing increased use following successes in protecting against COVID-19, elucidating the underlying mechanisms of action is essential to maximize their potential. Read about how IL-1 and IL-1ra can regulate the inflammatory response to RNA vaccines.​​​​​

 

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