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TriLink BioTechnologies社 November TriLink Messenger

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Research News
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Cloaking mRNA to Control Stability and Translation in Cells

The thermal and enzymatic instability of RNA present challenges to practical aspects of mRNA vaccines and therapeutics, imposing limits on mRNA analysis, storage, transportation, and pharmacology. In this month's Zon blog, we are taking a closer look at cloaking mRNA to control their stability and translation in cells.

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Directed evolution of Cas9 broadens PAM sequence compatibility 


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Individualized self-amplifying mRNA neoantigen vaccines promise improved outcomes for cancer patients
Researchers at the Broad Institute of MIT and Harvard substitute TriLink’s N1-methyl-pseudouridine and CleanCap® AG in New England Biolabs HiScribe™ T7 High Yield RNA Synthesis Kit to validate a novel method for directed evolution of Cas9, which resulted in variants targeting previously inaccessible PAM sequences in the human genome.
 
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TriLink recently manufactured self-amplifying mRNA for a phase I clinical trial, which showed that individualized, T cell inducing vaccines improved outcomes for cancer patients when administered with checkpoint inhibitor therapies. Find out more in our research spotlight.

 

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