Since conventional silica gels are weakly acidic, some pH sensitive compounds may be decomposed during the purification by column chromatography with the acidic silica gels. The pH of Silica Gel 60 (spherical neutral) is adjusted to nearly neutral for the separation of not only pH sensitive compounds but also new compounds that the physical properties are still unknown.
*All chromatograms shown below are obtained with silica gel packed into stainless and steel columns.

Comparison with conventional silica gel

Purification of Acetal

Condition
Column size	4.6 mm I.D. x 250 mm	Sample	Sample A (100 mg/ml)
Mobile phase	ethyl acetate : hexane = 1 : 99
Flow rate	1.0 ml/min
Temperature	30°C
Detection	UV 254 nm, 0.08AUFS
Internal standard	Methyl Benzoate (10mg/ml)	Injection vol.	3 µl

Condition
Column size	4.6 mm I.D. x 250 mm	Sample	Sample B (200 mg/ml)
Mobile phase	ethyl acetate : hexane = 1 : 99
Flow rate	1.0 ml/min
Temperature	30°C
Detection	UV 254 nm, 0.08AUFS
Internal standard	Methyl Benzoate (10 mg/ml)	Injection vol.	3 µl

Ordering information

Silica Gel 60 (spherical, neutral)

Product Name	PKG size	Product No.
Silica Gel 60, spherical, neutral, avg. particle size 75 µm
	100 g	30511-64
	500 g	30511-35
	1 kg	30511-51
	5 kg	30511-06
	25 kg	30511-22
Silica Gel 60, spherical, neutral, avg. particle size 140 µm
	500 g	30518-65
	1 kg	30518-81
	25 kg	30518-52